Does your genome interpretation software do this?    The CytoVA module of MutationForecaster®  can!

Every gene variant imported into CUVD from our other genome interpretation modules can be searched in several external databases seamlessly. Currently, all LOVD locus specific databases, dbSNP, ClinVar, and the Exome Variant Server are searched together and  variants found in any of these resources  are added to CUVD and hyperlinked when the search is completed. Until today, only one variant at a time could be searched.

As of today, CUVD is now able to simultaneously search and retrieve these data from batches of multiple variants with a single request (see below). Select all or just a group of variants in your database.  MutationForecaster® estimates how long the search will take and notifies you when the task is complete. For example, searching 20 variants takes just over 1 minute. Replace outdated results when the databases are updated simply by repeating the search.  Sign up for your free trial of MutationForecaster and try this exciting feature yourself!

The final version of our paper:

Dorman S, Baranova K, Knoll J, Urquhart, B, Marciani G, Carcangiu M-L, and Rogan PK.  Genomic signatures for Paclitaxel and Gemcitabine resistance in breast cancer derived by machine learning. Mol. Oncology 10: 85-100, 2015. doi: 10.1016/j.molonc.2015.07.006

is available in print and here:  Dorman etal Mol. Onc.10:85-100, 2016

We are excited to be able to offer our customers and registrants this opportunity to experience our integrated suite of genome interpretation products. For the first time, Cytognomix is offering a free trial of our MutationForecaster® genome interpretation suite to all registrants of the product. No subscription is required to analyze data with any of our software tools.  Trial users are provided with the same datasets that we have analyzed in our peer-reviewed publications. Start your trial whenever you’re ready.

The trial showcases many capabilities available to subscribers:

1. Run all of our major software products with their built-in filters:

• Automated Splice Site and Exon Definition Analysis (ASSEDA)
• Shannon Splicing Mutation Pipeline
• Veridical
• Variant Effect Predictor (VEP)
• Cytognomics Visualization Analytics for literature and genomic validation (CytoVA)
• Cytognomix User Variation Database (CUVD)

2.  Customize results with any of these products:

• Alter parameters and change information models in ASSEDA
• Custom filtering of results obtained from the Shannon pipeline, Veridical, and VEP
• Run literature or cytogenomic-based queries of Medline with CytoVA
• Export results to CUVD, which you can search, modify, or analyze variants with a wide variety of external databases then archive results of searches
• Download results from any product

3.  Streamline analysis of a dataset with all of these products in a single run using Workflows

Once you see the discoveries that only MutationForecaster® can make, we are confident that you will sign up for a subscription to analyze your own data.

Contact us if you have questions about the trial.

Happy holidays!

“Predicting response to adjuvant chemotherapy with genomic signatures derived by machine learning”
Department of Oncology, London Regional Cancer Program, University of Western Ontario.

The lecture room was packed and many oncologists attended!